Nibaldo C Inestrosa Selected Research

hyperforin

2/2016	Tetrahydrohyperforin (IDN5706) targets the endoplasmic reticulum for autophagy activation: potential mechanism for Alzheimer's disease therapy.
4/2015	Tetrahydrohyperforin: a neuroprotective modified natural compound against Alzheimer's disease.
1/2013	Tetrahydrohyperforin induces mitochondrial dynamics and prevents mitochondrial Ca2+ overload after Aβ and Aβ-AChE complex challenge in rat hippocampal neurons.
1/2013	Tetrahydrohyperforin increases adult hippocampal neurogenesis in wild-type and APPswe/PS1ΔE9 mice.
3/2010	The hyperforin derivative IDN5706 occludes spatial memory impairments and neuropathological changes in a double transgenic Alzheimer's mouse model.

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Nibaldo C Inestrosa Research Topics

Disease

88	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 04/2002
34	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021 - 03/2003
24	Amyloid Plaque 01/2021 - 04/2002
12	Cognitive Dysfunction 01/2021 - 01/2005
6	Dementia (Dementias) 10/2021 - 12/2004
6	Nervous System Diseases (Neurological Disorders) 04/2019 - 01/2013
6	Prion Diseases (Transmissible Spongiform Encephalopathies) 01/2006 - 03/2003
5	Neuroinflammatory Diseases 01/2021 - 01/2013
5	Neoplasms (Cancer) 01/2021 - 03/2016
4	Gliosis 02/2020 - 06/2004
4	Memory Disorders (Memory Loss) 12/2017 - 08/2012
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 12/2018 - 05/2016
3	Mitochondrial Diseases (Mitochondrial Disease) 11/2017 - 01/2013
3	Inflammation (Inflammations) 01/2017 - 03/2014
3	Fibrosis (Cirrhosis) 01/2016 - 01/2015
3	Inclusion Body Myositis 01/2015 - 01/2009
2	Heart Failure 01/2022 - 12/2021
2	Prostatic Neoplasms (Prostate Cancer) 01/2021 - 01/2019
2	Obesity 04/2019 - 10/2014
2	Carcinogenesis 01/2019 - 01/2015
2	Bipolar Disorder (Manic Depressive Psychosis) 03/2016 - 02/2016
2	Central Nervous System Lupus Vasculitis 06/2015 - 01/2015
2	Hypertension (High Blood Pressure) 01/2015 - 10/2014
2	Neuroblastoma 09/2008 - 10/2003
1	Cardiac Arrhythmias (Arrythmia) 12/2021
1	Vascular Diseases (Vascular Disease) 12/2021
1	Neurocognitive Disorders (Clerambault Syndrome) 01/2021
1	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 01/2021
1	Autistic Disorder (Autism) 01/2021
1	Neoplasm Metastasis (Metastasis) 01/2021
1	Parkinson Disease (Parkinson's Disease) 02/2019
1	Pathologic Processes 01/2019
1	Non-alcoholic Fatty Liver Disease 12/2018
1	Insulin Resistance 12/2018

Drug/Important Bio-Agent (IBA)

46	Amyloid (Amyloid Fibrils)IBA 01/2021 - 04/2002
26	Peptides (Polypeptides)IBA 01/2021 - 12/2005
24	Amyloid beta-PeptidesIBA 01/2020 - 04/2002
17	Proteins (Proteins, Gene)FDA Link 01/2018 - 07/2002
11	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 10/2014
10	AcetylcholinesteraseIBA 01/2013 - 04/2002
7	Cholinergic Agents (Cholinergics)IBA 03/2015 - 12/2003
6	CateninsIBA 01/2021 - 01/2013
6	EnzymesIBA 01/2019 - 01/2004
6	CopperIBA 07/2011 - 10/2002
6	Prion ProteinsIBA 01/2006 - 03/2003
5	andrographolideIBA 11/2021 - 12/2014
5	FructoseIBA 01/2021 - 10/2014
5	LigandsIBA 01/2019 - 05/2007
5	tau Proteins (tau Protein)IBA 01/2018 - 08/2012
5	hyperforinIBA 02/2016 - 03/2010
4	Pharmaceutical PreparationsIBA 01/2021 - 11/2008
4	Transcription Factors (Transcription Factor)IBA 12/2017 - 06/2010
4	beta CateninIBA 06/2010 - 07/2005
3	PotassiumIBA 01/2022 - 12/2015
3	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2005
3	Neuroprotective AgentsIBA 01/2019 - 12/2014
3	MetalsIBA 01/2017 - 01/2006
3	Phosphotransferases (Kinase)IBA 10/2016 - 12/2009
3	LithiumIBA 03/2016 - 11/2008
3	Glial Fibrillary Acidic ProteinIBA 12/2015 - 10/2003
3	Protein Isoforms (Isoforms)IBA 01/2006 - 01/2006
2	Neurotransmitter Agents (Neurotransmitter)IBA 01/2021 - 01/2011
2	Methionine (L-Methionine)FDA Link 02/2020 - 11/2015
2	Interleukin-6 (Interleukin 6)IBA 02/2020 - 12/2015
2	CalciumIBA 11/2016 - 01/2013
2	Imatinib Mesylate (Gleevec)FDA Link 10/2016 - 09/2008
2	Biological ProductsIBA 10/2016 - 01/2009
2	MicroRNAs (MicroRNA)IBA 05/2016 - 01/2015
2	Peroxisome ProliferatorsIBA 01/2016 - 01/2013
2	rheinIBA 01/2016 - 03/2014
2	AntigensIBA 06/2015 - 01/2015
2	Anti-ribosomal P protein autoantibodiesIBA 06/2015 - 01/2015
2	Angiotensin IIIBA 02/2015 - 01/2015
2	Wnt ProteinsIBA 12/2013 - 06/2013
2	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 12/2013 - 01/2013
2	Caspase 3 (Caspase-3)IBA 01/2013 - 09/2008
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2013 - 03/2003
2	Cholinesterase Inhibitors (Anticholinesterases)IBA 02/2008 - 01/2004
1	Propranolol (Inderal)FDA LinkGeneric 12/2021
1	huperzine AIBA 10/2021
1	AlkaloidsIBA 10/2021
1	HexosesIBA 01/2021
1	perchlorateIBA 01/2021
1	Endocrine DisruptorsIBA 01/2021
1	IodineIBA 01/2021
1	Amino Acids FDA Link 02/2020
1	HomocysteineIBA 02/2020
1	Therapeutic UsesIBA 02/2020
1	AdiponectinIBA 04/2019
1	Thyroid HormonesIBA 04/2019
1	ResistinIBA 04/2019
1	AdipokinesIBA 04/2019
1	ParaquatIBA 02/2019
1	SolutionsIBA 12/2018
1	QuercetinIBA 11/2017
1	Adenosine Triphosphate (ATP)IBA 09/2017
1	Propylthiouracil FDA Link 01/2017

Therapy/Procedure

10	Therapeutics 01/2021 - 01/2006
1	Traditional Medicine (Folk Remedies) 10/2021
1	Transcutaneous Electric Nerve Stimulation (TENS) 01/2019